Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA3 | P07451 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
| ▸ | CA6 | P23280 | 3/20 | 0.38 |
| ▸ | CA5A | P35218 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369131 | 1.00 | KDM4E (0.44) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL6369134 | 0.95 | KDM4E (0.42) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL7597289 | 0.82 | KDM4E (0.52) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL7597293 | 0.82 | KDM4E (0.52) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL9101771 | 0.77 | KDM4E (0.52) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL9101781 | 0.77 | KDM4E (0.52) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL29999634 | 0.72 | KDM4E (0.49) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL14898033 | 0.70 | KDM4E (0.50) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL4283078 | 0.69 | THRB (0.56) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 | |
| SCHEMBL4283080 | 0.69 | THRB (0.56) | KDM4EALOX5HDAC1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050101540-A1 | STAT modulators | AMGEN INC. (US) | 2005-05-12 | — | — | US | disclosed |
| US-6884782-B2 | STAT modulators | AMGEN INC. (US) | 2005-04-26 | — | — | US | disclosed |
| US-20020151504-A1 | STAT modulators | TULARIK INC. | 2002-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151504-A1 | STAT modulators | STAT6, STAT4, STAT3 | KDM4E 688/4885ALOX5 2337/4885HDAC1 242/4885 |
| US-20050101540-A1 | STAT modulators | STAT6, STAT4, STAT3 | KDM4E 688/4885ALOX5 2337/4885HDAC1 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.