Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368768 | 0.93 | TRPC5 (0.41) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL6369495 | 0.91 | TRPC5 (0.40) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL6369592 | 0.89 | TRPC5 (0.39) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL15372705 | 0.88 | TRPC5 (0.46) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL6369056 | 0.87 | TRPC5 (0.39) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL4860778 | 0.86 | TRPC5 (0.39) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL540713 | 0.85 | TRPC5 (0.39) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL29429566 | 0.85 | TRPC5 (0.39) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL14002615 | 0.85 | TRPC5 (0.49) | TRPC5ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL8250779 | 0.85 | TRPC5 (0.49) | TRPC5ALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896449-B1 | HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES | JANSSEN R & D IRELAND (IE) | 2013-11-06 | — | — | EP | disclosed |
| US-8178694-B2 | Heterocyclylaminoalkyl substituted benzimidazoles | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-05-15 | — | — | US | disclosed |
| US-8178694-B2 | Heterocyclylaminoalkyl substituted benzimidazoles | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-05-15 | — | — | US | disclosed |
| US-20100272683-A1 | HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES | JANSSEN SCIENCES IRELAND UC (IE) | 2010-10-28 | — | — | US | disclosed |
| US-20100272683-A1 | HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES | JANSSEN SCIENCES IRELAND UC (IE) | 2010-10-28 | — | — | US | disclosed |
| WO-2006136562-A1 | HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100272683-A1 | HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES | HRH4, HTR4, HTR3C | TRPC5 1157/4885ALDH1A1 482/4885MEN1 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.