Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PYGL | P06737 | 12/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NHERF1 | O14745 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369645 | 0.96 | POLB (0.55) | POLBKDM4ENPC1MAPTKMT2A | |
| SCHEMBL6772117 | 0.80 | NPC1 (0.71) | POLBKDM4ENPC1MAPTKMT2A | |
| SCHEMBL26535585 | 0.73 | HSF1 (0.58) | POLBKDM4ENPC1MAPTKMT2A | |
| SCHEMBL17968670 | 0.73 | MEN1 (0.54) | POLBKMT2APYGLMEN1RXFP1 | |
| SCHEMBL6368672 | 0.73 | PYGL (0.51) | POLBKDM4ENPC1MAPTKMT2A | |
| SCHEMBL28524834 | 0.71 | MEN1 (0.54) | KMT2APYGLMEN1RXFP1NHERF1 | |
| SCHEMBL29634197 | 0.71 | MEN1 (0.54) | KMT2APYGLMEN1RXFP1NHERF1 | |
| SCHEMBL29634221 | 0.71 | PYGL (0.53) | KMT2APYGLMEN1RXFP1NHERF1 | |
| SCHEMBL28533979 | 0.71 | PYGL (0.53) | KMT2APYGLMEN1RXFP1NHERF1 | |
| SCHEMBL28525293 | 0.70 | PYGL (0.52) | KMT2APYGLMEN1RXFP1NHERF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020661-A1 | Substituted 1H-indole-2- carboxamides and 6H-thieno(2,3-b)pyrrole-5-carboxamides useful for inhibiting glycogen phosphorylase in a mammal | GAMMILL RONALD B (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020661-A1 | Substituted 1H-indole-2- carboxamides and 6H-thieno(2,3-b)pyrrole-5-carboxamides useful for inhibiting glycogen phosphorylase in a mammal | PYGM, PYGL, IRS1 | POLB 1190/4885KDM4E 1273/4885NPC1 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.