Ecabapide

Ecabapide

SCHEMBL637042

CNC(=O)c1cccc(NCC(=O)NCCc2ccc(OC)c(OC)c2)c1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.56
▸ ALDH1A1 P00352 2/20 0.55
▸ HPGD P15428 1/20 0.55
▸ ALOX12 P18054 1/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.55
▸ KMT2A Q03164 4/20 0.54
▸ HTT P42858 1/20 0.54
▸ MAPK1 P28482 1/20 0.53
▸ NAMPT P43490 1/20 0.53
▸ POLB P06746 1/20 0.52
▸ MEN1 O00255 3/20 0.51
▸ GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ecabapide SCHEMBL29367862 1.00 MAPT (0.56) MAPTALDH1A1HPGDALOX12SMN1; SMN2
Ecabapide SCHEMBL29367974 1.00 MAPT (0.56) MAPTALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL9063062 0.91 MAPK1 (0.54) MAPTALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL9063229 0.90 MAPK1 (0.56) MAPTALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL9769115 0.89 KMT2A (0.56) MAPTALDH1A1HPGDALOX12SMN1; SMN2
Water SCHEMBL9769056 0.88 KMT2A (0.55) MAPTALDH1A1HPGDALOX12SMN1; SMN2
Hydrochloric Acid SCHEMBL11274170 0.88 KMT2A (0.55) MAPTALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL9063049 0.87 KMT2A (0.53) MAPTALDH1A1HPGDALOX12SMN1; SMN2
Hydrochloric Acid SCHEMBL6370914 0.85 F2 (0.55) MAPTALDH1A1HPGDALOX12SMN1; SMN2
SCHEMBL11282670 0.84 ERCC1 (0.65) MAPTALDH1A1SMN1; SMN2KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 338 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
EP-2560634-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS Piramal Enterprises Limited (IN) 2013-02-27 — — EP claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 — — US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 — — US claimed
WO-2011132171-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-10-27 — — WO claimed
US-20110263526-A1 Nitric Oxide Releasing Prodrugs of Therapeutic Agents PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-10-27 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
WO-2010038241-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING OF PROTON PUMP INHIBITOR, PROKINETIC AGENT AND ALGINIC ACID PANACEA BIOTEC LIMITED (IN) 2010-04-08 — — WO claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 — — US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 — — US claimed
EP-1596838-A2 ONCE A DAY ORALLY ADMINISTERED PHARMACEUTICAL COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR AND A PROKINETIC AGENT Torrent Pharmaceuticals Ltd (IN) 2005-11-23 — — EP claimed
WO-2004071374-A2 ONCE A DAY ORALLY ADMINISTERED PHARMACEUTICAL COMPOSITIONS TORRENT PHARMACEUTICALS LIMITED (IN) 2004-08-26 — — WO claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
CN-1343128-A Medicinal compositions DAICHI PHARMACEUTICAL CO LTD (JP) 2002-04-03 — — CN claimed
EP-0697215-A1 DIGESTIVE SYMPTOM AMELIORANT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1996-02-21 — — EP claimed
US-4985595-A Anti-peptic Ulcer Agents DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1991-01-15 — — US claimed
EP-0185368-B1 AMINOBENZAMIDE DERIVATIVES DAIICHI SEIYAKU CO., LTD. (JP) 1990-06-06 — — EP claimed
EP-0185368-A2 Aminobenzamide derivatives DAIICHI SEIYAKU CO., LTD. (JP) 1986-06-25 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263526-A1 Nitric Oxide Releasing Prodrugs of Therapeutic Agents NOS2, NOS1, NOS3 MAPT 4304/4885ALDH1A1 204/4885HPGD 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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