Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 15/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14457146 | 0.90 | LTB4R (0.45) | LTB4RLTB4R2PPARGPPARACYSLTR2 | |
| SCHEMBL11012956 | 0.86 | L3MBTL1 (0.41) | LTB4RLTB4R2PPARGPPARAPPARD | |
| SCHEMBL8583246 | 0.85 | CYP4F2 (0.50) | LTB4RLTB4R2PPARGPPARA | |
| SCHEMBL4931425 | 0.80 | NFKB1 (0.37) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL10639016 | 0.77 | LTB4R (0.60) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL23911581 | 0.76 | NFKB1 (0.41) | LTB4RLTB4R2 | |
| SCHEMBL14457830 | 0.76 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL4794533 | 0.76 | NFKB1 (0.41) | LTB4RLTB4R2 | |
| SCHEMBL7552930 | 0.75 | LTB4R (0.47) | LTB4RLTB4R2 | |
| SCHEMBL7557806 | 0.75 | LTB4R (0.47) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593478-A1 | LEUKOTRIENE B 4? ANTAGONISTS. | SEARLE & CO (US) | 1994-04-27 | — | — | EP | claimed |
| US-6933272-B1 | Use of non-peptidyl compounds for the treatment of insulin related ailments | HELMERHORST ERIK (AU) | 2005-08-23 | — | — | US | disclosed |
| WO-2001034133-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |
| US-5684162-A | BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-11-04 | — | — | US | disclosed |