Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154654 | 0.94 | HMGCR (0.59) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7526269 | 0.91 | HMGCR (0.56) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL2187676 | 0.85 | HMGCR (0.60) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| Calcium SCHEMBL2278710 | 0.83 | HMGCR (0.58) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7084466 | 0.82 | HMGCR (0.74) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9373479 | 0.81 | HMGCR (0.52) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL78134 | 0.80 | MEN1 (0.61) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1704691 | 0.80 | HMGCR (1.00) | HMGCRMEN1KMT2AGAAALDH1A1 | |
| Apomine SCHEMBL1648488 | 0.80 | HMGCR (1.00) | HMGCR | |
| Calcium SCHEMBL912231 | 0.79 | MEN1 (0.59) | HMGCRMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888365-B1 | A process for the preparation of diphosphonate derivatives | SYMPHAR SA (CH) | 2002-05-08 | — | — | EP | claimed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | claimed |
| EP-0339237-B1 | PHENOL SUBSTITUTED GEM-DIPHOSPHONATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1992-12-30 | — | — | EP | claimed |
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | claimed |
| US-5043330-A | Antiinflammatory and hypotensive agents; antihyperlipemia | SYMPHAR S.A. (CH) | 1991-08-27 | — | — | US | claimed |
| WO-2011163389-A2 | METHOD FOR INDUCING FAT LOSS IN MAMMALS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-12-29 | — | — | WO | disclosed |
| US-20050124586-A1 | Alpha-substituted arylalkyl phosphonate derivatives | ILEX PRODUCTS, INC. | 2005-06-09 | — | — | US | disclosed |
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | disclosed |
| EP-0888365-B1 | A process for the preparation of diphosphonate derivatives | SYMPHAR SA (CH) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | disclosed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | disclosed |
| US-6048995-A | Process for the preparation of diphosphonate derivatives | SYMPHAR S.A. (CH) | 2000-04-11 | — | — | US | disclosed |
| EP-0888365-A1 | A PROCESS FOR THE PREPARATION OF DIPHOSPHONATE DERIVATIVES | SYMPHAR S.A. (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997031004-A1 | A PROCESS FOR THE PREPARATION OF DIPHOSPHONATE DERIVATIVES | SYMPHAR S.A. (CH) | 1997-08-28 | — | — | WO | disclosed |
| US-5153183-A | Antiarthritic agents | TORAY INDUSTRIES, INC. (JP) | 1992-10-06 | — | — | US | disclosed |
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | disclosed |
| US-5043330-A | Antiinflammatory and hypotensive agents; antihyperlipemia | SYMPHAR S.A. (CH) | 1991-08-27 | — | — | US | disclosed |
| EP-0440809-A1 | METHYLENEDIPHOSPHONIC ACID COMPOUND AND ANTI-INFLAMMATORY CONTAINING THE SAME AS ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 1991-08-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124586-A1 | Alpha-substituted arylalkyl phosphonate derivatives | APOB, APOL1, LDLR | HMGCR 117/4885MEN1 4414/4885KMT2A 2698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.