Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cicletanine SCHEMBL16859315 | 1.00 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL637073 | 1.00 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL6060344 | 1.00 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL29915570 | 1.00 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL49794 | 1.00 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL387011 | 0.99 | KDM4E (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL29633447 | 0.99 | KDM4E (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL1649704 | 0.97 | KDM4E (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| Cicletanine SCHEMBL6479989 | 0.94 | MEN1 (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL3798183 | 0.86 | KDM4E (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326652-B1 | NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS | MERCK SHARP & DOHME (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8119806-B2 | Cicletanine derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100029678-A1 | DIURETICS | MERCK SHARP & DOHME CORP. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029678-A1 | DIURETICS | NR3C2, REN, NR3C1 | MEN1 2133/4885KMT2A 1778/4885KDM4E 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.