Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cicletanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.30 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.30 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.30 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.30 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.30 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cicletanine SCHEMBL387011 | 1.00 | KDM4E (0.35) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL637385 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL29915570 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL6060344 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL49794 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL637073 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL16859315 | 0.99 | MEN1 (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL1649704 | 0.96 | KDM4E (0.35) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| Cicletanine SCHEMBL6479989 | 0.92 | MEN1 (0.35) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3798183 | 0.85 | KDM4E (0.36) | KDM4EMEN1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026047264-A1 | MACHINE FOR THE AUTOMATED PRODUCTION OF TEQUEÑOS (FILLED PASTRIES ) OR OTHER SIMILAR CULINARY PRODUCTS | MORA IBARRA CARLOS LUIS (ES) | 2026-03-05 | — | — | WO | disclosed |
| WO-2024243651-A1 | HYBRID PROPULSION SYSTEM FOR VTOL AIRCRAFT | PEREIRA FILHO ALBERTO CARLOS (BR) | 2024-12-05 | — | — | WO | disclosed |
| WO-2023237804-A1 | METHOD FOR OPTIMISING ENERGY MANAGEMENT IN A SOLAR ENERGY INSTALLATION WITH STORAGE MEANS IN COMBINATION WITH CHARGING AN ELECTRIC VEHICLE AND ASSOCIATED SYSTEM | TURBO ENERGY, S.L. (ES) | 2023-12-14 | — | — | WO | disclosed |
| CN-115104620-A | Furan nicotine insecticidal composition and application thereof | 山东恒利达生物科技有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-114840686-A | Knowledge graph construction method, device and equipment based on metadata and storage medium | 中国电信股份有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-11372218-B2 | Imaging lens and manufacturing method of light-shielding element | RAYS OPTICS INC. (TW) | 2022-06-28 | — | — | US | disclosed |