Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 14/20 | 0.68 |
| ▸ | ESR1 | P03372 | 13/20 | 0.68 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374651 | 1.00 | ESR2 (0.68) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL4746340 | 0.89 | ESR2 (0.69) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL4746337 | 0.89 | ESR2 (0.69) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL17988306 | 0.89 | CYP1A2 (0.66) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL28348198 | 0.89 | CYP1A2 (0.66) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL6374891 | 0.84 | MGLL (0.65) | ESR2ESR1MGLLCA12CA1 | |
| SCHEMBL6374895 | 0.84 | MGLL (0.65) | ESR2ESR1MGLLCA12CA1 | |
| SCHEMBL5072943 | 0.78 | ESR2 (0.56) | ESR2ESR1MGLLCYP3A4CA12 | |
| SCHEMBL11263514 | 0.73 | ALDH1A1 (0.48) | ESR2ESR1MGLLCYP1A2CYP3A4 | |
| SCHEMBL10661875 | 0.72 | ESR1 (0.53) | ESR2ESR1MGLLCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050159465-A1 | 3-(4-Hydroxy-2-methylphenyl)-1,2-benzisoxazol-6-ol; estrogen receptor modulators; ability to compete with 17 beta -estradiol for both Estrogen Receptor alpha and Estrogen Receptor beta; Estrogen Receptor Selective Agonist Antagonist activity; anticancer, antiinflammatory, anticholesterol | WYETH (US) | 2005-07-21 | — | — | US | disclosed |
| US-6884814-B2 | Phenyl benzisoxazoles as estrogenic agents | WYETH (US) | 2005-04-26 | — | — | US | disclosed |
| US-20030207927-A1 | Phenyl benzisoxazoles as estrogenic agents | WYETH | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207927-A1 | Phenyl benzisoxazoles as estrogenic agents | ESR1, ESR2, GPER1 | ESR2 2/4885ESR1 1/4885MGLL 4581/4885 |
| US-20050159465-A1 | 3-(4-Hydroxy-2-methylphenyl)-1,2-benzisoxazol-6-ol; estrogen receptor modulators; ability to compete with 17 beta -estradiol for both Estrogen Receptor alpha and Estrogen Receptor beta; Estrogen Receptor Selective Agonist Antagonist activity; anticancer, antiinflammatory, anticholesterol | ESR2, ESR1, GPER1 | ESR2 1/4885ESR1 2/4885MGLL 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.