SCHEMBL6374712

SCHEMBL6374712

O=C(Nc1ccc(Cl)cc1)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(N2CCCCC2=O)cc1

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 6/20 0.58
▸ TSHR P16473 2/20 0.51
▸ FPR2 P25090 10/20 0.50
▸ LMNA P02545 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ MAPT P10636 1/20 0.47
▸ MMP1 P03956 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6374720 1.00 F10 (0.58) F10TSHRFPR2LMNAHPGD
SCHEMBL6376598 1.00 F10 (0.58) F10TSHRFPR2LMNAHPGD
SCHEMBL6374223 0.97 F10 (0.56) F10TSHRFPR2LMNAHPGD
SCHEMBL6374212 0.97 F10 (0.56) F10TSHRFPR2LMNAHPGD
SCHEMBL6374263 0.97 F10 (0.56) F10TSHRFPR2LMNAHPGD
SCHEMBL5433595 0.91 F10 (0.56) F10TSHRLMNAHPGDMAPT
SCHEMBL5434232 0.87 F10 (0.60) F10TSHRFPR2LMNAHPGD
SCHEMBL5429178 0.87 F10 (0.74) F10TSHRFPR2LMNAHPGD
SCHEMBL6376266 0.86 FPR1 (0.55) FPR2
SCHEMBL5428324 0.86 F10 (0.59) F10TSHRFPR2LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050137230-A1 Carboxamide derivatives DORSCH DIETER (DE) 2005-06-23 — — US claimed
US-20040038858-A1 Carboxamide derivatives and their use in the treatment of thromboembolic diseases and tumours MERCK PATENT GMBH (DE) 2004-02-26 — — US claimed
US-20050137230-A1 Carboxamide derivatives DORSCH DIETER (DE) 2005-06-23 — — US disclosed
US-20040038858-A1 Carboxamide derivatives and their use in the treatment of thromboembolic diseases and tumours MERCK PATENT GMBH (DE) 2004-02-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050137230-A1 Carboxamide derivatives F11, F12, F2 F10 4/4885TSHR 1409/4885FPR2 766/4885
US-20040038858-A1 Carboxamide derivatives and their use in the treatment of thromboembolic diseases and tumours CNR2, CNR1, HCAR2 F10 117/4885TSHR 587/4885FPR2 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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