Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836300 | 0.98 | HSD17B10 (0.46) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL3836308 | 0.89 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL636595 | 0.89 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL2585744 | 0.89 | CYP1A2 (0.55) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL5013691 | 0.88 | ALDH1A1 (0.39) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| SCHEMBL2592020 | 0.88 | ALDH1A1 (0.41) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| SCHEMBL2581158 | 0.86 | ALDH1A1 (0.40) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL11123125 | 0.85 | KMT2A (0.46) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| Bicarbonate SCHEMBL11031888 | 0.85 | ALDH1A1 (0.41) | HSD17B10ALDH1A1HPGDCYP1A2THRB | |
| SCHEMBL6255235 | 0.84 | SLC9A1 (0.37) | HSD17B10ALDH1A1HPGDCYP1A2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452863-A2 | Process for treating wastes from waste waters obtained from the production of dyes | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-23 | — | — | EP | claimed |
| EP-0176899-B1 | MIXED CRYSTALS OF PIGMENTS ON THE BASIS OF DIIMIDES OF PERYLENE TETRACARBOXYLIC ACID, THEIR MANUFACTURING PROCESS AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | claimed |
| EP-0113437-B1 | ELECTROPHOTOGRAPHIC RECORDING MATERIAL | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | claimed |
| EP-0176899-A2 | Mixed crystals of pigments on the basis of diimides of perylene tetracarboxylic acid, their manufacturing process and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | claimed |
| EP-0113437-A1 | Electrophotographic recording material | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-18 | — | — | EP | claimed |
| EP-3515990-B1 | METHOD FOR MANUFACTURING LIGNOCELLULOSE WORKPIECES | BASF SE (DE) | 2020-07-08 | — | — | EP | disclosed |
| EP-3376228-B1 | METHODFOR DETECTING BIOGENIC AMINE MESSENGER MATERIALS | KARLSRUHER INST TECHNOLOGIE (DE) | 2020-02-12 | — | — | EP | disclosed |
| EP-3274143-B1 | METHOD FOR MANUFACTURING WOODEN MATERIALS | BASF SE (DE) | 2019-08-28 | — | — | EP | disclosed |
| EP-3515990-A1 | METHOD FOR PRODUCING LIGNOCELLULOSE MATERIALS | BASF SE (DE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2019115261-A1 | METHOD FOR PRODUCING SINGLE- OR MULTI-LAYER LIGNOCELLULOSE MATERIALS UNDER SPECIFIC CONDITIONS IN A HOT PRESS | BASF SE (DE) | 2019-06-20 | — | — | WO | disclosed |
| EP-3376228-A2 | METHOD FOR DETECTING BIOGENIC AMINE MESSENGER MATERIALS | Karlsruher Institut für Technologie (DE) | 2018-09-19 | — | — | EP | disclosed |
| WO-2018054732-A1 | METHOD FOR PRODUCING LIGNOCELLULOSE MATERIALS | BASF SE (DE) | 2018-03-29 | — | — | WO | disclosed |
| EP-0113437-B1 | ELECTROPHOTOGRAPHIC RECORDING MATERIAL | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | disclosed |
| EP-0224784-A2 | Carbazole group-containing polysiloxane, photoconductive layers and electrophotographic material | BASF Aktiengesellschaft (DE) | 1987-06-10 | — | — | EP | disclosed |
| EP-0176899-A2 | Mixed crystals of pigments on the basis of diimides of perylene tetracarboxylic acid, their manufacturing process and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-09 | — | — | EP | disclosed |
| EP-0039482-B1 | PERYLENE-3,4,9,10-TETRACARBOXYLIC ACID MONOANHYDRIDE-MONOIMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-03-27 | — | — | EP | disclosed |
| EP-0113437-A1 | Electrophotographic recording material | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-18 | — | — | EP | disclosed |
| EP-0035218-B1 | PERYLENE-3,4,9,10-TETRACARBOXYLIC-ACID-MONOANHYDRIDE-MONOALKALI SALTS, PROCESS FOR THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-01-11 | — | — | EP | disclosed |
| EP-0047027-A1 | Liquid crystals mixture | BBC Aktiengesellschaft Brown, Boveri & Cie. (CH) | 1982-03-10 | — | — | EP | disclosed |
| EP-0039482-A2 | Perylene-3,4,9,10-tetracarboxylic acid monoanhydride-monoimides, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-11-11 | — | — | EP | disclosed |