Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CASR | P41180 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | IAPP | P10997 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604379 | 0.92 | CYP4Z1 (0.46) | CYP4F2CYP4A11APPCYP2D6CASR | |
| SCHEMBL3348357 | 0.89 | CYP4F2 (0.54) | CYP4F2CYP4A11APPCYP2D6CASR | |
| SCHEMBL1337425 | 0.84 | CYP4F2 (0.55) | CYP4F2CYP4A11APPCYP2D6CASR | |
| SCHEMBL6416677 | 0.82 | CYP4F2 (0.52) | CYP4F2CYP4A11APPCYP2D6CASR | |
| SCHEMBL30291871 | 0.82 | APP (0.73) | CYP4F2CYP4A11APPCYP4Z1IAPP | |
| SCHEMBL490911 | 0.82 | APP (0.73) | CYP4F2CYP4A11APPCYP4Z1IAPP | |
| SCHEMBL7605997 | 0.81 | CYP4F2 (0.51) | CYP4F2CYP4A11CYP2D6CASRADRB2 | |
| SCHEMBL7608755 | 0.81 | CYP4Z1 (0.46) | CYP4F2CYP4A11APPCYP2D6CASR | |
| SCHEMBL8984895 | 0.81 | CYP4F2 (0.61) | CYP4F2CYP4A11APPCYP4Z1IAPP | |
| SCHEMBL1549436 | 0.81 | CYP4F2 (0.61) | CYP4F2CYP4A11APPCYP4Z1IAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070048-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |