Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.46 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.46 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6376291 | 0.92 | CYP4F2 (0.54) | CYP4Z1CYP4F2CYP4A11APPCYP2D6 | |
| SCHEMBL7608755 | 0.90 | CYP4Z1 (0.46) | CYP4Z1CYP4F11CYP4F12CYP4F2CYP4A11 | |
| SCHEMBL3348357 | 0.81 | CYP4F2 (0.54) | CYP4Z1CYP4F2CYP4A11APPCYP2D6 | |
| SCHEMBL7606028 | 0.80 | ALOX5 (0.50) | CYP4Z1CYP4F11CYP4F12CYP4F2CYP4A11 | |
| SCHEMBL7602907 | 0.79 | CASR (0.46) | CYP4Z1CYP4F11CYP4F12CYP4F2CYP4A11 | |
| SCHEMBL8466268 | 0.79 | CYP4Z1 (0.54) | CYP4Z1CYP4F11CYP4F12CYP4F2CYP4A11 | |
| SCHEMBL11127882 | 0.78 | NPC1 (0.50) | MAPK1NPSR1CYP2D6CYP3A4SMN1; SMN2 | |
| SCHEMBL7604752 | 0.77 | MGLL (0.48) | CYP4Z1CYP4F11CYP4F12TNFCYP2D6 | |
| SCHEMBL7604748 | 0.77 | MGLL (0.48) | CYP4Z1CYP4F11CYP4F12TNFCYP2D6 | |
| SCHEMBL2769855 | 0.77 | KAT8 (0.53) | MAPK1NPSR1CYP3A4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |