Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 5/20 | 0.46 |
| ▸ | ALPL | P05186 | 5/20 | 0.46 |
| ▸ | XIAP | P98170 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369236 | 0.98 | TSHR (0.48) | TSHRENPP3ALPLXIAPALDH1A1 | |
| Acetic Acid SCHEMBL10353741 | 0.89 | TSHR (0.50) | TSHRENPP3ALPLXIAPALDH1A1 | |
| Nitric Acid SCHEMBL637677 | 0.86 | NPC1 (0.48) | TSHRENPP3ALPLXIAPALDH1A1 | |
| Nitric Acid SCHEMBL28996492 | 0.84 | NPC1 (0.47) | TSHRENPP3ALPLXIAPALDH1A1 | |
| Hydrochloric Acid SCHEMBL9124540 | 0.82 | ALDH1A1 (0.49) | TSHRENPP3ALPLXIAPALDH1A1 | |
| SCHEMBL22622062 | 0.80 | TSHR (0.52) | TSHRENPP3ALPLXIAPALDH1A1 | |
| SCHEMBL9123767 | 0.79 | ALDH1A1 (0.50) | TSHRENPP3ALPLXIAPALDH1A1 | |
| SCHEMBL3185391 | 0.79 | NOS1 (0.42) | TSHRENPP3ALPLXIAPALDH1A1 | |
| SCHEMBL6454758 | 0.78 | TSHR (0.50) | TSHRENPP3ALPLXIAPALDH1A1 | |
| SCHEMBL15459000 | 0.78 | TSHR (0.50) | TSHRENPP3ALPLXIAPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112121765-B | Environment-friendly formaldehyde-removing activated carbon and preparation method thereof | 品顾科技(苏州)有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114015355-A | High-viscosity anti-slip rubber asphalt waterproof coating | 上海豫宏（金湖）防水科技有限公司 | 2022-02-08 | — | — | CN | claimed |
| CN-112111211-B | Environment-friendly coating | 佛山威迪科彩色装饰涂料有限公司 | 2021-10-22 | — | — | CN | claimed |
| US-5453514-A | Diabetes | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-26 | — | — | US | claimed |
| CN-112121765-B | Environment-friendly formaldehyde-removing activated carbon and preparation method thereof | 品顾科技(苏州)有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114015355-A | High-viscosity anti-slip rubber asphalt waterproof coating | 上海豫宏（金湖）防水科技有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-112111211-B | Environment-friendly coating | 佛山威迪科彩色装饰涂料有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-112121765-A | Environment-friendly formaldehyde-removing activated carbon and preparation method thereof | 张艺峰 | 2020-12-25 | — | — | CN | disclosed |
| CN-112111211-A | Environment-friendly coating | 张艺峰 | 2020-12-22 | — | — | CN | disclosed |
| CN-105523997-A | 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride preparation method | TIANJIN HEOWNS BIOCHEMISTRY TECH CO LTD | 2016-04-27 | — | — | CN | disclosed |
| CN-105523997-A | 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride preparation method | TIANJIN HEOWNS BIOCHEMISTRY TECH CO LTD | 2016-04-27 | — | — | CN | disclosed |
| EP-1197486-B1 | Process for the preparation of 1H-pyrazole-1-carboxamidines | DEGUSSA (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-6410745-B1 | REACTION OF PYRAZOLE OR A DERIVATIVE THEREOF WITH CYANAMIDE OR A DERIVATIVE THEREOF AND GASEOUS HYDROGEN CHLORIDE OR HYDROGEN BROMIDE IN AN APROTIC SOLVENT. | DEGUSSA AG (DE) | 2002-06-25 | — | — | US | disclosed |
| US-20020045762-A1 | PROCESS FOR PREPARING 1-GUANYLPYRAZOLE ACID ADDUCTS | DEGUSSA AG (DE) | 2002-04-18 | — | — | US | disclosed |
| EP-1197486-A1 | Process for the preparation of 1H-pyrazole-1-carboxamidines | Degussa AG (DE) | 2002-04-17 | — | — | EP | disclosed |
| US-5814580-A | FORMING A CHELATE DYE BY THE REACTION OF AN AZOMETHINE DYE WITH A METAL-ION CONTAINING COMPOUND; EXCELLENT LIGHT FASTNESS | KONICA CORPORATION (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0732220-A1 | Thermal transfer recording material | KONICA CORPORATION (JP) | 1996-09-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045762-A1 | PROCESS FOR PREPARING 1-GUANYLPYRAZOLE ACID ADDUCTS | GLRA1, CYC1, CBR3 | TSHR 2206/4885ENPP3 2663/4885ALPL 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.