Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6379762 | 0.89 | KDM4E (0.78) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL9620764 | 0.86 | ACHE (0.51) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL5358840 | 0.85 | ACHE (0.59) | ACHE | |
| SCHEMBL4726216 | 0.81 | KDM4E (0.78) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL28939537 | 0.78 | KDM4E (0.60) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL28546898 | 0.77 | ACHE (0.44) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL29992097 | 0.77 | KDM4E (0.55) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL29868504 | 0.75 | ACHE (0.69) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL1658828 | 0.74 | KDM4E (0.71) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL18093460 | 0.73 | ALDH1A1 (0.81) | KDM4EMEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047674-B1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | EISAI CO LTD (JP) | 2005-03-30 | — | — | EP | disclosed |
| EP-1047674-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036405-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVE | EISAI CO., LTD. (JP) | 1999-07-22 | — | — | WO | disclosed |