Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 1.00 |
| ▸ | METAP1 | P53582 | 2/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.57 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378133 | 0.90 | CYP19A1 (0.81) | CYP19A1METAP1PDE4D | |
| SCHEMBL6827615 | 0.88 | CYP19A1 (1.00) | CYP19A1CYP26A1CYP24A1 | |
| SCHEMBL5582351 | 0.87 | CYP19A1 (0.77) | CYP19A1METAP1CYP26A1CYP24A1 | |
| SCHEMBL5582493 | 0.85 | CYP19A1 (0.73) | CYP19A1METAP1CYP26A1CYP24A1 | |
| SCHEMBL30462610 | 0.85 | CYP19A1 (0.73) | CYP19A1METAP1CYP26A1CYP24A1 | |
| SCHEMBL1114939 | 0.83 | PDE4D (0.81) | CYP19A1PDE4D | |
| SCHEMBL17313353 | 0.81 | CYP19A1 (0.68) | CYP19A1METAP1CYP26A1CYP24A1 | |
| SCHEMBL6384704 | 0.80 | CYP19A1 (0.67) | CYP19A1PDE4D | |
| SCHEMBL6825978 | 0.80 | CYP19A1 (1.00) | CYP19A1PDE4DCYP26A1CYP24A1 | |
| Hydrochloric Acid SCHEMBL2338476 | 0.79 | ACHE (0.74) | CYP19A1METAP1CYP26A1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531806-A4 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS | WYETH CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1531806-A2 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS | Wyeth (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1047674-B1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | EISAI CO LTD (JP) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000225-A2 | USE OF THIO-OXINDOLE DERIVATIVES IN TREATMENT OF HORMONE-RELATED CONDITIONS | WYETH (US) | 2003-12-31 | — | — | WO | disclosed |