Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.81 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.71 |
| ▸ | ACHE | P22303 | 10/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382100 | 0.87 | PDE4D (0.71) | PDE4DCYP19A1ACHE | |
| SCHEMBL15700137 | 0.86 | ACHE (0.80) | PDE4DACHE | |
| SCHEMBL6378133 | 0.83 | CYP19A1 (0.81) | PDE4DCYP19A1ACHE | |
| SCHEMBL6378154 | 0.83 | CYP19A1 (1.00) | PDE4DCYP19A1 | |
| SCHEMBL12306070 | 0.82 | CYP19A1 (0.65) | PDE4DCYP19A1ACHE | |
| SCHEMBL17320351 | 0.82 | PDE4D (0.58) | PDE4DACHE | |
| SCHEMBL6383533 | 0.81 | PDE4D (0.57) | PDE4DCYP19A1ACHE | |
| SCHEMBL15906580 | 0.81 | ACHE (0.58) | PDE4DACHE | |
| SCHEMBL6381232 | 0.79 | CYP19A1 (1.00) | PDE4DCYP19A1ACHE | |
| Hydrochloric Acid SCHEMBL2331841 | 0.79 | ACHE (0.98) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | claimed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | claimed |
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | disclosed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | disclosed |
| US-9376387-B2 | Oxidisable pyridine derivatives, their preparation and use as anti-alzheimer agents | INSA INST NAT DES SCIENCES APPLIQUEES DE ROUEN (FR) | 2016-06-28 | — | — | US | disclosed |
| US-9376387-B2 | Oxidisable pyridine derivatives, their preparation and use as anti-alzheimer agents | INSA INST NAT DES SCIENCES APPLIQUEES DE ROUEN (FR) | 2016-06-28 | — | — | US | disclosed |
| US-20150353493-A1 | OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS | INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (FR) | 2015-12-10 | — | — | US | disclosed |
| US-20150353493-A1 | OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS | INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (FR) | 2015-12-10 | — | — | US | disclosed |
| EP-2278970-B1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LTD (IN) | 2015-04-22 | — | — | EP | disclosed |
| EP-2278970-B1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LTD (IN) | 2015-04-22 | — | — | EP | disclosed |
| US-8987458-B2 | Process for the preparation of donepezil hydrochloride | CIPLA LIMITED (IN) | 2015-03-24 | — | — | US | disclosed |
| WO-2005003092-A1 | PREPARATION OF INTERMEDIATES FOR ACETYL CHOLINESTERASE INHIBITORS | HETERO DRUGS LIMITED (IN) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003092-A1 | PREPARATION OF INTERMEDIATES FOR ACETYL CHOLINESTERASE INHIBITORS | HETERO DRUGS LIMITED (IN) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004082685-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND DERIVATIVES THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-30 | — | — | WO | disclosed |
| US-6706741-B2 | ALZHEIMER*S DISEASE | EISAI CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1285656-A1 | ACETYLCHOLINESTERASE INHIBITORS CONTAINING 1-BENZYL- PYRIDINIUM SALTS | Eisai Co., Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
| US-6252081-B1 | REDUCING OF THE COORRESPONDING QUATERNARY AMMONIUM SALT | EISAI CO., LTD. (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-1047674-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036405-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVE | EISAI CO., LTD. (JP) | 1999-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353493-A1 | OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS | CBR3, CBR1, CYB5R3 | PDE4D 4191/4885CYP19A1 791/4885ACHE 675/4885 |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | ACHE, CHRM1, BCHE | PDE4D 1506/4885CYP19A1 1333/4885ACHE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.