Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381145 | 0.78 | TBK1 (0.50) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9526335 | 0.77 | KDM4E (0.51) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL1825884 | 0.73 | PARP1 (0.53) | HSD17B10ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL28946476 | 0.73 | GSK3B (0.59) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL15661524 | 0.71 | PDE10A (0.42) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL2202173 | 0.69 | BCL2L1 (0.54) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL6445055 | 0.69 | ADORA1 (0.60) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL6960194 | 0.67 | SNCA (0.56) | ALDH1A1MAPTMEN1KMT2AADORA1 | |
| SCHEMBL30132131 | 0.67 | ALDH1A1 (0.58) | HSD17B10ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL11820723 | 0.66 | PDE10A (0.66) | ALDH1A1KDM4EHPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057485-B1 | POTASSIUM CHANNEL ACTIVATORS | NIPPON SHINYAKU CO LTD (JP) | 2005-05-11 | — | — | EP | claimed |
| US-6353016-B1 | PYRROLE COMPOUNDS FOR POTASSIUM CHANNEL ACTIVATORS | NIPPON SHINYAKU CO., LTD. (JP) | 2002-03-05 | — | — | US | claimed |
| EP-1057485-A1 | POTASSIUM CHANNEL ACTIVATORS | Nippon Shinyaku Co., Ltd. (JP) | 2000-12-06 | — | — | EP | claimed |
| EP-1057485-B1 | POTASSIUM CHANNEL ACTIVATORS | NIPPON SHINYAKU CO LTD (JP) | 2005-05-11 | — | — | EP | disclosed |
| US-6353016-B1 | PYRROLE COMPOUNDS FOR POTASSIUM CHANNEL ACTIVATORS | NIPPON SHINYAKU CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1057485-A1 | POTASSIUM CHANNEL ACTIVATORS | Nippon Shinyaku Co., Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |