Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.44 |
| ▸ | PDE4A | P27815 | 7/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381761 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2ADORA2BLMNAABCC8KCNJ11 | |
| SCHEMBL6383655 | 0.82 | PDE4A (0.35) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL6380593 | 0.78 | PDE4A (0.48) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL2957435 | 0.76 | PDE4A (0.48) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL6381937 | 0.74 | P2RX7 (0.40) | SMN1; SMN2ADORA2BMAPTLMNAABCC8 | |
| SCHEMBL6381655 | 0.70 | PDE4A (0.52) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5771868 | 0.69 | TRPA1 (0.41) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL28319203 | 0.68 | ADORA2B (0.56) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL6383651 | 0.67 | KMT2A (0.37) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5790131 | 0.67 | TRPA1 (0.38) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1557165-A1 | COMBINATION DRUG | Eisai Co., Ltd. (JP) | 2005-07-27 | — | — | EP | disclosed |