Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 8/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378913 | 0.83 | MMP13 (0.56) | MMP13CTSLCTSBPTPN1MMP14 | |
| SCHEMBL6379044 | 0.80 | MMP13 (0.50) | MMP13CTSLCTSBPTPN1MMP14 | |
| SCHEMBL6379256 | 0.79 | MMP13 (0.59) | MMP13CTSLCTSBMMP14 | |
| SCHEMBL6377050 | 0.78 | MMP13 (0.54) | MMP13CTSLCTSBPTPN1MMP14 | |
| SCHEMBL6383331 | 0.77 | MMP13 (0.54) | MMP13CTSLCTSBPTPN1MMP14 | |
| SCHEMBL6379245 | 0.77 | CTSL (0.48) | MMP13CTSLCTSBPTPN1MAOB | |
| SCHEMBL6379189 | 0.75 | CTSL (0.49) | MMP13CTSLCTSBPTPN1MAOB | |
| SCHEMBL6378028 | 0.71 | MMP13 (0.43) | MMP13PTPN1MMP14MAOBAPP | |
| SCHEMBL6375133 | 0.71 | CA12 (0.56) | MMP13CTSLCTSBPTPN1MMP14 | |
| SCHEMBL6377388 | 0.71 | MAOB (0.49) | MMP13CTSLCTSBPTPN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |