Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378746 | 0.82 | PLA2G7 (0.49) | MMP13MMP14PTPN1MAOBPLA2G7 | |
| SCHEMBL6378459 | 0.81 | PLA2G7 (0.43) | MMP13MMP14PTPN1MAOBPLA2G7 | |
| SCHEMBL6380894 | 0.81 | MAOB (0.47) | PTPN1MAOBPLA2G7APPMAOA | |
| SCHEMBL6383331 | 0.77 | MMP13 (0.54) | MMP13MMP14PTPN1MAOBAPP | |
| SCHEMBL6380903 | 0.71 | MMP13 (0.46) | MMP13MMP14PTPN1MAOBKCNH2 | |
| SCHEMBL6378913 | 0.66 | MMP13 (0.56) | MMP13MMP14PTPN1MAOBAPP | |
| SCHEMBL6379044 | 0.65 | MMP13 (0.50) | MMP13MMP14PTPN1MAOBAPP | |
| SCHEMBL6378851 | 0.65 | MMP13 (0.47) | MMP13MMP14PTPN1OPRM1OPRD1 | |
| SCHEMBL6382057 | 0.65 | MMP13 (0.75) | MMP13MMP14PTPN1MAOBAPP | |
| SCHEMBL6379245 | 0.65 | CTSL (0.48) | MMP13PTPN1MAOBAPPMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1202974-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012611-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2001-02-22 | — | — | WO | disclosed |