Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 6/20 | 0.59 |
| ▸ | PPARA | Q07869 | 6/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | BAX | Q07812 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560281 | 0.91 | LDHA (0.65) | LDHAPPARGPPARACYP1A2GAA | |
| SCHEMBL28451520 | 0.83 | PPARG (0.59) | PPARGPPARAPARP10SRD5A2LTA4H | |
| SCHEMBL9656870 | 0.80 | CYP1A2 (0.73) | PPARGPPARAPTGS1CYP1A2GAA | |
| SCHEMBL9362383 | 0.80 | CYP1A2 (0.73) | PPARGPPARAPTGS1CYP1A2GAA | |
| SCHEMBL995776 | 0.79 | LDHA (0.52) | LDHAPPARGPPARAPARP10CYP1A2 | |
| SCHEMBL10970589 | 0.79 | LDHA (0.52) | LDHAPPARGPPARACYP1A2GAA | |
| SCHEMBL4564099 | 0.79 | LDHA (0.52) | LDHAPPARGPPARAPTGS1CYP1A2 | |
| SCHEMBL10335497 | 0.79 | LDHA (0.52) | LDHAPPARGPPARACYP1A2GAA | |
| Hydrochloric Acid SCHEMBL9366029 | 0.79 | CYP1A2 (0.71) | PPARGPPARAPTGS1CYP1A2GAA | |
| Hydrochloric Acid SCHEMBL9362752 | 0.79 | CYP1A2 (0.71) | PPARGPPARAPTGS1CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1202974-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012611-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2001-02-22 | — | — | WO | disclosed |