Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Becatecarin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 12/20 | 0.47 |
| ▸ | PRKCA | P17252 | 11/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.70 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | PRKCH | P24723 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Becatecarin SCHEMBL5953787 | 0.97 | PRKCA (0.78) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Becatecarin SCHEMBL31237559 | 0.97 | PRKCA (0.78) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Becatecarin SCHEMBL5953888 | 0.97 | PRKCA (0.78) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Becatecarin SCHEMBL29378739 | 0.97 | PRKCA (0.78) | PRKCADYRK1APAX8PRKD3PRKCG | |
| SCHEMBL6385491 | 0.94 | PRKCA (0.67) | PRKCADYRK1APAX8PRKD3PRKCG | |
| SCHEMBL26846490 | 0.90 | PRKCA (0.65) | PRKCADYRK1APAX8PRKD3PRKCG | |
| SCHEMBL14498686 | 0.84 | PRKCA (0.57) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Rebeccamycin SCHEMBL12961242 | 0.83 | DYRK1A (1.00) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Rebeccamycin SCHEMBL30194716 | 0.83 | DYRK1A (1.00) | PRKCADYRK1APAX8PRKD3PRKCG | |
| Rebeccamycin SCHEMBL14069957 | 0.83 | DYRK1A (1.00) | PRKCADYRK1APAX8PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050228490-A1 | Medical devices to treat or inhibit restenosis | MEDTRONIC VASCULAR, INC. (US) | 2005-10-13 | — | — | US | disclosed |