Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMO | O15229 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | TET3 | O43151 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202448 | 0.88 | ALDH1A1 (0.61) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| SCHEMBL31151693 | 0.88 | ALDH1A1 (0.61) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| SCHEMBL29026601 | 0.86 | ALDH1A1 (0.59) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| Hydrochloric Acid SCHEMBL27576045 | 0.86 | ALDH1A1 (0.59) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| SCHEMBL9440140 | 0.86 | ALDH1A1 (0.59) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| Hydrochloric Acid SCHEMBL1682029 | 0.86 | ALDH1A1 (0.59) | KDM4CALDH1A1MAPTL3MBTL1KMO | |
| SCHEMBL177518 | 0.81 | KDM4C (0.62) | KDM4CALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL30155195 | 0.81 | KDM4C (0.62) | KDM4CALDH1A1MAPTL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL700397 | 0.79 | KDM4C (0.60) | KDM4CALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL899382 | 0.74 | MAPT (0.59) | KDM4CALDH1A1MAPTL3MBTL1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076488-B2 | Antiproliferative agents; angiogenesis inhibitors; anticancer agents | BAYER HEALTHCARE LLC (US) | 2011-12-13 | — | — | US | disclosed |
| EP-1608639-A2 | NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050038031-A1 | Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders | BAYER HEALTHCARE LLC | 2005-02-17 | — | — | US | disclosed |
| WO-2004078748-A2 | NOVEL BICYCLIC UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038031-A1 | Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders | CCNC, UACA, SLC14A1 | KDM4C 926/4885ALDH1A1 1861/4885MAPT 1011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.