Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386918 | 1.00 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2PARP1PARP10 | |
| SCHEMBL6391832 | 0.84 | CYP11B1 (0.44) | CYP19A1CYP11B1CYP11B2ADRA2AADRA1A | |
| SCHEMBL6391836 | 0.84 | CYP11B1 (0.44) | CYP19A1CYP11B1CYP11B2ADRA2AADRA1A | |
| SCHEMBL6387837 | 0.79 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2PARP1PARP10 | |
| SCHEMBL6385964 | 0.72 | KMT2A (0.44) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL6385968 | 0.72 | KMT2A (0.44) | CYP19A1CYP11B1CYP11B2CYP17A1MEN1 | |
| SCHEMBL18266929 | 0.70 | CYP19A1 (0.42) | CYP19A1CYP11B1CYP11B2PARP1PARP10 | |
| SCHEMBL18816496 | 0.68 | BRAF (0.46) | NPC1BRAFMAPK3MAPK1RAB9A | |
| SCHEMBL18795055 | 0.68 | BRAF (0.46) | NPC1BRAFMAPK3MAPK1RAB9A | |
| SCHEMBL354990 | 0.68 | LMNA (0.49) | CYP19A1CYP11B1CYP11B2PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | OPRK1, RECQL, OPRM1 | CYP19A1 763/4885CYP11B1 500/4885CYP11B2 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.