Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409589 | 0.83 | PTGS2 (0.75) | PTGS2PTGS1 | |
| SCHEMBL5422320 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL6722703 | 0.81 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL6726597 | 0.80 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL6721381 | 0.79 | PTGS2 (0.79) | PTGS2PTGS1 | |
| SCHEMBL6821187 | 0.79 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL6389023 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6723191 | 0.77 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL6729026 | 0.77 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL6950710 | 0.76 | PTGS2 (0.71) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878726-B2 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PFIZER INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20050004135-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | CHENG HENGMAIO (US) | 2005-01-06 | — | — | US | disclosed |
| US-20040259879-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | CHENG HENGMAIO (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1259504-A1 | PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | Pfizer Products Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020058681-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2002-05-16 | — | — | US | disclosed |
| WO-2001064669-A1 | PYRAZOLE ETHER DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PRODUCTS INC. (US) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058681-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PTGER3, PTGER1, P2RX3 | PTGS2 96/4885PTGS1 34/4885 |
| US-20050004135-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | P2RX3, P2RX7, PTGER3 | PTGS2 257/4885PTGS1 124/4885 |
| US-20040259879-A1 | Pyrazole ether derivatives as anti-inflammatory/analgesic agents | PTGER3, PTGER1, P2RX3 | PTGS2 96/4885PTGS1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.