Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815855 | 0.79 | KDM4E (0.53) | CYP1A2CYP3A4TSHRKDM4EALDH1A1 | |
| SCHEMBL6396188 | 0.79 | FLT3 (0.54) | HRH4FLT3KDM4EALDH1A1HPGD | |
| SCHEMBL6866887 | 0.76 | PDGFRB (1.00) | PDGFRBPDGFRAMEN1KMT2AFLT3 | |
| SCHEMBL12334808 | 0.75 | HRH4 (0.81) | PDGFRBPDGFRAMEN1KMT2AHRH4 | |
| SCHEMBL10820775 | 0.75 | KMT2A (1.00) | MEN1KMT2ATSHRHDAC6KDM4E | |
| SCHEMBL335235 | 0.75 | PDGFRB (0.79) | PDGFRBPDGFRAMEN1KMT2AFLT3 | |
| SCHEMBL2729934 | 0.75 | PDGFRB (0.79) | PDGFRBPDGFRAMEN1KMT2AFLT3 | |
| SCHEMBL10821170 | 0.74 | KMT2A (0.94) | MEN1KMT2ATSHRHDAC6KDM4E | |
| SCHEMBL25667602 | 0.74 | HRH4 (0.59) | MEN1KMT2AHRH4FLT3HDAC6 | |
| SCHEMBL1429381 | 0.74 | PDGFRB (0.77) | PDGFRBPDGFRAMEN1KMT2AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050267303-A1 | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals | ZENTARIS AG | 2005-12-01 | — | — | US | disclosed |
| US-20040039197-A1 | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals | WATERWORKS, INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267303-A1 | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals | IDO1, IDO2, INMT | PDGFRB 3507/4885PDGFRA 3410/4885MEN1 279/4885 |
| US-20040039197-A1 | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals | IDO1, IDO2, INMT | PDGFRB 3464/4885PDGFRA 3317/4885MEN1 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.