Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110140 | 0.87 | CYP19A1 (0.55) | CYP19A1CYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL1186098 | 0.82 | CES2 (0.49) | KDM4ECYP11B1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL6389593 | 0.79 | PDGFRB (0.60) | KDM4ECYP1A2CYP3A4ALDH1A1HPGD | |
| SCHEMBL7290470 | 0.78 | NPC1 (0.49) | CYP1A2CYP3A4CYP1A1CYP2D6CYP1B1 | |
| SCHEMBL5821865 | 0.77 | PTGS2 (0.58) | CYP1A2MAPTTSHR | |
| SCHEMBL13028396 | 0.77 | FAAH (0.46) | CYP19A1CYP3A4ALDH1A1HPGDMAPT | |
| SCHEMBL27431185 | 0.77 | HSD11B1 (0.43) | KDM4ECYP3A4ALDH1A1HSD17B10KLK7 | |
| SCHEMBL8335586 | 0.77 | NOS2 (0.42) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL9807751 | 0.77 | CYP19A1 (0.46) | CYP19A1CYP3A4MAPTTBXAS1 | |
| Hydrochloric Acid SCHEMBL11181766 | 0.76 | ALPG (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | KDM4E 2898/4885CYP11B1 1508/4885CYP11B2 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.