Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.75 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PARG | Q86W56 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6393638 | 0.91 | MMP13 (0.80) | MMP13SLC22A8MAPTPARGGRM4 | |
| SCHEMBL6388683 | 0.89 | MMP13 (0.74) | MMP13SLC22A8MAPTTP53SMN1; SMN2 | |
| SCHEMBL6395655 | 0.88 | MMP13 (0.81) | MMP13SLC22A8PARGSRC | |
| SCHEMBL6390652 | 0.88 | MMP13 (0.78) | MMP13SLC22A8MAPTSMN1; SMN2PARG | |
| SCHEMBL6391740 | 0.88 | MMP13 (0.78) | MMP13SLC22A8MAPTPARGHIF1A | |
| SCHEMBL6392298 | 0.86 | MMP13 (0.69) | MMP13SLC22A8MAPTTP53SMN1; SMN2 | |
| SCHEMBL6392558 | 0.86 | MMP13 (0.72) | MMP13SLC22A8PARGGRM4 | |
| SCHEMBL6244295 | 0.86 | MMP13 (1.00) | MMP13SLC22A8SMN1; SMN2PARGALDH1A1 | |
| SCHEMBL6390967 | 0.85 | MMP13 (0.87) | MMP13SLC22A8SMN1; SMN2PARGALDH1A1 | |
| SCHEMBL6394445 | 0.85 | MMP13 (0.71) | MMP13SLC22A8MAPTTP53PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962922-B2 | Alkynylated quinazoline compounds | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-08 | — | — | US | claimed |
| US-20050245548-A1 | Alkynylated fused ring pyrimidine compounds | GAUDILLIERE BERNARD | 2005-11-03 | — | — | US | claimed |
| EP-1465878-A1 | ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | claimed |
| WO-2004007469-A1 | NEW ALKYNYLATED QUINAZOLIN COMPOUNDS AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | claimed |
| US-20030130278-A1 | Alkynylated fused ring pyrimidine compounds | GAUDILLIERE BERNARD (FR) | 2003-07-10 | — | — | US | claimed |
| WO-2003033478-A1 | ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | claimed |
| US-6962922-B2 | Alkynylated quinazoline compounds | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-08 | — | — | US | disclosed |
| US-20050245548-A1 | Alkynylated fused ring pyrimidine compounds | GAUDILLIERE BERNARD | 2005-11-03 | — | — | US | disclosed |
| US-6911515-B2 | Aqueous room temperature living radical polymerization of vinyl halides | UNIVERSITY OF PENNSYLVANIA (US) | 2005-06-28 | — | — | US | disclosed |
| US-6838535-B2 | Process for the living radical polymerization of chlorine containing monomers | UNIVERSITY OF PENNSYLVANIA (US) | 2005-01-04 | — | — | US | disclosed |
| EP-1465878-A1 | ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2004007469-A1 | NEW ALKYNYLATED QUINAZOLIN COMPOUNDS AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |
| US-20030130278-A1 | Alkynylated fused ring pyrimidine compounds | GAUDILLIERE BERNARD (FR) | 2003-07-10 | — | — | US | disclosed |
| US-20030078353-A1 | Aqueous room temperature living radical polymerization of vinyl halides | UNIVERSITY OF PENNSYLVANIA | 2003-04-24 | — | — | US | disclosed |
| WO-2003033478-A1 | ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2002077043-A1 | PROCESS FOR THE LIVING RADICAL POLYMERIZATION OF CHLORINE CONTAINING MONOMERS | UNIVERSITY OF PENNSYLVANIA (US) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130278-A1 | Alkynylated fused ring pyrimidine compounds | MMP13, TIMP3, MMP3 | MMP13 1/4885SLC22A8 811/4885MAPT 4840/4885 |
| US-20050245548-A1 | Alkynylated fused ring pyrimidine compounds | MMP13, TIMP3, MMP3 | MMP13 1/4885SLC22A8 827/4885MAPT 4823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.