SCHEMBL6396202

SCHEMBL6396202

Nc1cccc(-c2nc3c(N)cccc3s2)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.65
KDM4E B2RXH2 6/20 0.65
RAB9A P51151 6/20 0.65
ALDH1A1 P00352 5/20 0.65
NPC1 O15118 4/20 0.65
MEN1 O00255 4/20 0.65
KMT2A Q03164 4/20 0.65
NFKB1 P19838 4/20 0.65
NFKB2 Q00653 4/20 0.65
RELA Q04206 4/20 0.65
GAA P10253 4/20 0.60
SMN1; SMN2 Q16637 4/20 0.60
GLA P06280 3/20 0.60
HPGD P15428 3/20 0.60
POLB P06746 3/20 0.60
PKM P14618 2/20 0.60
TP53 P04637 2/20 0.60
HSD17B10 Q99714 2/20 0.60
PTBP1 P26599 1/20 0.60
CASP1 P29466 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3385440 0.85 KDM4E (0.50) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL6403729 0.83 APP (0.60) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL4905437 0.81 MAPT (0.57) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL10873450 0.80 MAPT (0.73) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL30776283 0.79 RAB9A (1.00) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL2242693 0.79 RAB9A (1.00) MAPTKDM4ERAB9AALDH1A1NPC1
2-Phenylbenzo[D]Thiazole SCHEMBL12479298 0.78 APP (0.62) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL6401979 0.75 MAPT (0.77) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL11749206 0.75 MAPT (1.00) MAPTKDM4ERAB9AALDH1A1NPC1
SCHEMBL13470771 0.75 NPC1 (0.61) MAPTKDM4ERAB9AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4321363-A Adsorbent for urokinase containing agarose NIPPON SODA COMPANY LIMITED (JP) 1982-03-23 US claimed
US-20050170077-A1 Adhesion method SHIPLEY COMPANY, L.L.C. (US) 2005-08-04 US disclosed
US-20040161545-A1 Adhesion method SHIPLEY COMPANY, L.L.C. 2004-08-19 US disclosed
EP-0464371-A1 Polyamic acid structures, and methods of fabrication thereof International Business Machines Corporation (US) 1992-01-08 EP disclosed
US-5004627-A Polyimides for mold release ETHYL CORPORATION (US) 1991-04-02 US disclosed
EP-0249744-B1 PROCESS FOR MAKING POLYIMIDE-METAL LAMINATES AKZO N.V. (NL) 1989-10-11 EP disclosed
EP-0167020-B1 FLEXIBLE POLYIMIDE MULTILAYER LAMINATE Akzo Patente GmbH (DE) 1988-11-23 EP disclosed
US-4746561-A Polyimide-containing cover layer for a printed circuit element AKZO N.V. (NL) 1988-05-24 US disclosed
EP-0249744-A1 Process for making polyimide-metal laminates AKZO N.V. (NL) 1987-12-23 EP disclosed
EP-0116297-B1 POLYIMIDE LAMINATE WITH PEEL-RESISTANCE AND METHOD OF MANUFACTURING IT Akzo GmbH (DE) 1987-12-02 EP disclosed
US-4705720-A FOR PRINTED CIRCUITS AKZO NV (NL) 1987-11-10 US disclosed
US-4699841-A PRINTED CIRCUITS AKZO NV (NL) 1987-10-13 US disclosed
US-4675246-A DIRECT BONDING WITH SUBSTRATE AND POLYIMIDE AKZO NV (NL) 1987-06-23 US disclosed
EP-0167020-A2 Flexible polyimide multilayer laminate Akzo Patente GmbH (DE) 1986-01-08 EP disclosed
US-4522880-A EXTRUSION ON SUBSTRATE, THEN CURING AKZONA INCORPORATED (US) 1985-06-11 US disclosed
EP-0116297-A2 Polyimide laminate with peel-resistance and method of manufacturing it Akzo GmbH (DE) 1984-08-22 EP disclosed
US-4321363-A Adsorbent for urokinase containing agarose NIPPON SODA COMPANY LIMITED (JP) 1982-03-23 US disclosed