Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3505988 | 0.96 | — | — | |
| Glycine SCHEMBL28861283 | 0.96 | GLRA1 (0.91) | — | |
| Glycine SCHEMBL433424 | 0.96 | — | — | |
| Glycine SCHEMBL6357710 | 0.96 | GLRA1 (0.91) | — | |
| Glycine SCHEMBL11056979 | 0.96 | GLRA1 (0.91) | — | |
| Glycine SCHEMBL5712832 | 0.96 | — | — | |
| Glycine SCHEMBL1650224 | 0.96 | GLRA1 (0.91) | — | |
| Glycine SCHEMBL22949 | 0.96 | — | — | |
| Glycine SCHEMBL4274286 | 0.96 | GLRA1 (0.91) | — | |
| Glycine SCHEMBL1555637 | 0.96 | GLRA1 (0.91) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1489174-B1 | METHOD OF MODIFYING PROTEIN PROPERTIES | NAT INST OF TECHNOLOGY AND EVALUATION (JP) | 2015-08-12 | — | — | EP | disclosed |
| US-20130316401-A1 | Method for Modifying a Property of a Protein | AJINOMOTO CO., INC. (JP) | 2013-11-28 | — | — | US | disclosed |
| US-8510053-B2 | Method for modifying a property of a protein | AJINOMOTO CO., INC. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-20050233308-A1 | Method for modifying a property of a protein | AJINOMOTO CO., INC. (JP) | 2005-10-20 | — | — | US | disclosed |
| EP-1489174-A1 | METHOD OF MODIFYING PROTEIN PROPERTIES | National Institute of Technology and Evaluation (JP) | 2004-12-22 | — | — | EP | disclosed |
| US-4020268-A | Agarose containing affinity matrix materials | XEROX CORPORATION (US) | 1977-04-26 | — | — | US | disclosed |