Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.91 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.91 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.91 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL22949 | 1.00 | — | — | |
| Glycine SCHEMBL5712832 | 1.00 | — | — | |
| Glycine SCHEMBL6396455 | 0.96 | — | — | |
| Glycine SCHEMBL29168877 | 0.96 | — | — | |
| Glycine SCHEMBL28665130 | 0.96 | — | — | |
| Glycine SCHEMBL583141 | 0.96 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL3640989 | 0.95 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL391786 | 0.95 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL93765 | 0.95 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| Glycine SCHEMBL391027 | 0.95 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082217-A1 | Selection of nucleic acid-based sensor domains within nucleic acid switch platform | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2009-03-26 | — | — | US | disclosed |
| WO-2009011855-A9 | SELECTION OF NUCLEIC ACID-BASED SENSOR DOMAINS WITHIN NUCLEIC ACID SWITCH PLATFORM | CALIFORNIA INST OF TECHN (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009011855-A2 | SELECTION OF NUCLEIC ACID-BASED SENSOR DOMAINS WITHIN NUCLEIC ACID SWITCH PLATFORM | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2009-01-22 | — | — | WO | disclosed |