Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389669 | 0.76 | L3MBTL1 (0.58) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL856770 | 0.73 | L3MBTL1 (0.71) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL10411023 | 0.72 | HTT (0.70) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL6396777 | 0.71 | KMT2A (0.97) | L3MBTL1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL6392101 | 0.70 | MEN1 (0.52) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17558052 | 0.70 | MEN1 (0.66) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL1101904 | 0.70 | KDM4E (0.55) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17563560 | 0.70 | MEN1 (0.57) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6670056 | 0.69 | MEN1 (0.66) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6394361 | 0.68 | L3MBTL1 (0.68) | L3MBTL1SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946115-B2 | Prodrugs for phosphorus-containing compounds | METABASIS THERAPEUTICS, INC. (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050065166-A1 | Substituted pyrimidines | BAYER CROPSCIENCE AG (DE) | 2005-03-24 | — | — | US | disclosed |
| EP-1444208-A1 | SUBSTITUTED PYRIMIDINES | Bayer CropScience AG (DE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003037878-A1 | SUBSTITUTED PYRIMIDINES | BAYER CROPSCIENCE AG (DE) | 2003-05-08 | — | — | WO | disclosed |
| US-20020052345-A1 | Novel prodrugs for phosphorus-containing compounds | METABASIS THERAPEUTICS, INC. | 2002-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065166-A1 | Substituted pyrimidines | DPYD, DHFR, TYMP | L3MBTL1 1248/4885SMN1; SMN2 2717/4885NPC1 4447/4885 |
| US-20020052345-A1 | Novel prodrugs for phosphorus-containing compounds | CCRL2, CCR4, ALK | L3MBTL1 1446/4885SMN1; SMN2 2218/4885NPC1 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.