Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.81 |
| ▸ | POLB | P06746 | 6/20 | 0.81 |
| ▸ | PKM | P14618 | 5/20 | 0.81 |
| ▸ | HPGD | P15428 | 7/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | RECQL | P46063 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | APEX1 | P27695 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 8/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 7/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243197 | 0.84 | MAPT (1.00) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL5283971 | 0.64 | MAPT (0.89) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL6391137 | 0.64 | MAPT (0.71) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL15679883 | 0.64 | MAPT (0.82) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL15426116 | 0.64 | MAPT (0.69) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL8156930 | 0.63 | MAPT (0.71) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL10036668 | 0.63 | MIF (1.00) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL14959208 | 0.62 | MAPT (0.69) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL15426114 | 0.62 | MAPT (0.70) | MAPTALDH1A1POLBPKMHPGD | |
| SCHEMBL5281834 | 0.62 | MAPT (0.74) | MAPTALDH1A1POLBPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | MAPT 1681/4885ALDH1A1 2627/4885POLB 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.