SCHEMBL6398232

SCHEMBL6398232

CC(C)[Si](OCO[C@H]1[C@H](n2ccc(=O)[nH]c2=O)O[C@@]2([SiH2]C2OC(C)(C)C)[C@H]1OC(C)(C)C)(C(C)C)C(C)C

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DUT P33316 3/20 0.35
▸ TDP1 Q9NUW8 1/20 0.33
▸ P2RY14 Q15391 1/20 0.32
▸ SLC28A1 O00337 1/20 0.31
▸ SLC28A2 O43868 1/20 0.31
▸ SLC29A1 Q99808 1/20 0.31
▸ SLC28A3 Q9HAS3 1/20 0.31
▸ P2RY2 P41231 1/20 0.30
▸ P2RY4 P51582 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6401808 0.84 LMNA (0.33) SLC29A1
SCHEMBL6403256 0.82 DUT (0.40) DUTTDP1P2RY14SLC28A1SLC28A2
SCHEMBL6401482 0.70 SLC28A1 (0.59) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL6401489 0.70 SLC28A1 (0.59) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL23243924 0.64 SLC28A1 (0.45) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL23069347 0.62 SLC28A1 (0.43) P2RY14SLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL18057138 0.62 P2RY6 (0.38) DUTP2RY14SLC28A1SLC28A2SLC29A1
SCHEMBL23710619 0.61 DUT (0.45) DUTP2RY14SLC28A1SLC28A2SLC29A1
SCHEMBL21418938 0.61 DUT (0.48) DUTP2RY14SLC28A1SLC28A2SLC29A1
SCHEMBL20503160 0.61 DUT (0.52) DUTP2RY14SLC28A1SLC28A2SLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050059817-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives SIRNA THERAPEUTICS, INC. (US) 2005-03-17 — — US disclosed
US-20020150936-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives RIBOZYME PHARMACEUTICALS, INC. 2002-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050059817-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives PNP, NSUN2, NT5C3B DUT 5/4885TDP1 1161/4885P2RY14 694/4885
US-20020150936-A1 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives PNP, NSUN2, NT5C3B DUT 6/4885TDP1 1182/4885P2RY14 799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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