Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.42 |
| ▸ | HTR7 | P34969 | 15/20 | 0.42 |
| ▸ | HTR1A | P08908 | 13/20 | 0.42 |
| ▸ | DRD2 | P14416 | 13/20 | 0.42 |
| ▸ | HTR2A | P28223 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205625 | 0.77 | TSHR (0.51) | HTR6HTR7HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL3338129 | 0.77 | TSHR (0.50) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL10205627 | 0.76 | L3MBTL1 (0.43) | HTR6HTR7HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL639140 | 0.75 | L3MBTL1 (0.42) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL641654 | 0.73 | KMT2A (0.49) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL639078 | 0.72 | EBP (0.48) | ALDH1A1 | |
| SCHEMBL21511854 | 0.71 | HTR6 (0.46) | HTR6HTR7DRD2HTR2AALDH1A1 | |
| SCHEMBL21512277 | 0.71 | HTR6 (0.46) | HTR6HTR7DRD2HTR2AALDH1A1 | |
| SCHEMBL3337535 | 0.71 | EBP (0.38) | HTR7ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL640337 | 0.70 | EBP (0.37) | HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119805-B2 | Substituted disulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | claimed |
| US-20100152158-A1 | Substituted Disulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-06-17 | — | — | US | claimed |
| US-8119805-B2 | Substituted disulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-8119805-B2 | Substituted disulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-8119805-B2 | Substituted disulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20100152158-A1 | Substituted Disulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
| US-20100152158-A1 | Substituted Disulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
| US-20100152158-A1 | Substituted Disulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152158-A1 | Substituted Disulfonamide Compounds | BDKRB1, BDKRB2, BRS3 | HTR6 792/4885HTR7 905/4885HTR1A 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.