SCHEMBL6399498

SCHEMBL6399498

Nc1ccc(-c2nc3cc(N)ccc3s2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 1.00
KDM4E B2RXH2 7/20 1.00
GAA P10253 6/20 1.00
NPC1 O15118 6/20 1.00
RAB9A P51151 6/20 1.00
ALDH1A1 P00352 5/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
POLB P06746 3/20 1.00
NFKB1 P19838 3/20 1.00
NFKB2 Q00653 3/20 1.00
RELA Q04206 3/20 1.00
GFER P55789 2/20 1.00
SMN1; SMN2 Q16637 4/20 0.76
TP53 P04637 3/20 0.76
GLA P06280 4/20 0.74
APP P05067 12/20 0.69
MMP9 P14780 1/20 0.69
MMP8 P22894 1/20 0.69
THRB P10828 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29918176 1.00 MAPT (1.00) MAPTKDM4EGAANPC1RAB9A
SCHEMBL2242138 0.90 MAPT (0.82) MAPTKDM4EGAANPC1RAB9A
SCHEMBL2244906 0.90 MAPT (0.81) MAPTKDM4EGAANPC1RAB9A
SCHEMBL19148568 0.90 MAPT (0.81) MAPTKDM4EGAANPC1RAB9A
SCHEMBL2245118 0.89 MAPT (0.81) MAPTKDM4EGAANPC1RAB9A
SCHEMBL15496408 0.89 MAPT (0.79) MAPTKDM4EGAANPC1RAB9A
SCHEMBL15510887 0.87 MAPT (0.77) MAPTKDM4EGAANPC1RAB9A
SCHEMBL19984988 0.86 APP (0.77) MAPTKDM4EGAANPC1RAB9A
SCHEMBL13391563 0.86 APP (0.77) MAPTKDM4EGAANPC1RAB9A
SCHEMBL5691159 0.86 APP (0.77) MAPTKDM4EGAANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240084484-A1 METHOD AND DEVICE FOR PREPARING MODIFIED POLY (M-PHENYLENE ISOPHTHALAMIDE) (PMIA) FIBER BY CONTINUOUS POLYMERIZATION-DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2024-03-14 US claimed
EP-4206370-A1 METHOD AND DEVICE FOR PREPARING MODIFIED META-ARAMID FIBERS BY MEANS OF CONTINUOUS POLYMERIZATION AND DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2023-07-05 EP claimed
CN-104992998-B Heat conduction backboard for crystalline silicon assembly, and preparation method thereof 杭州福斯特光伏材料股份有限公司 2017-01-18 CN claimed
CN-104191799-B A kind of preparation method of gum-free double side flexible copper coated board 杭州福斯特光伏材料股份有限公司 2016-08-17 CN claimed
CN-105778130-A High-strength high-heat-resistance polyimide microporous thin film and preparation method thereof 西北工业大学 2016-07-20 CN claimed
CN-104325774-B A kind of preparation method of two layers of gum-free double side flexible copper coated board 杭州福斯特光伏材料股份有限公司 2016-06-22 CN claimed
US-20050176700-A1 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases ACTELION PHARMACEUTICALS LTD. (CH) 2005-08-11 US claimed
US-20240084484-A1 METHOD AND DEVICE FOR PREPARING MODIFIED POLY (M-PHENYLENE ISOPHTHALAMIDE) (PMIA) FIBER BY CONTINUOUS POLYMERIZATION-DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2024-03-14 US disclosed
EP-4206370-A1 METHOD AND DEVICE FOR PREPARING MODIFIED META-ARAMID FIBERS BY MEANS OF CONTINUOUS POLYMERIZATION AND DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2023-07-05 EP disclosed
WO-2023039961-A1 METHOD AND DEVICE FOR PREPARING MODIFIED META-ARAMID FIBERS BY MEANS OF CONTINUOUS POLYMERIZATION AND DRY-WET SPINNING 株洲时代新材料科技股份有限公司 2023-03-23 WO disclosed
EP-3611224-A1 COMPOSITION, COMPOSITE FILM AND MEMBRANE ELECTRODE ASSEMBLY ASAHI KASEI KABUSHIKI KAISHA (JP) 2020-02-19 EP disclosed
CN-104066768-B Display base plate resin combination 日产化学工业株式会社 2018-03-23 CN disclosed
CN-104992998-B Heat conduction backboard for crystalline silicon assembly, and preparation method thereof 杭州福斯特光伏材料股份有限公司 2017-01-18 CN disclosed
US-4144231-A Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed
US-4144230-A Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed
US-4143033-A WATER-SOLUBLE DISAZO DYESTUFFS CONTAINING A 2-PHENYL-BENZIMIDAZOLYL,-BENZOXAZOLYL OR-BENZTHIAZOLYL MIDDLE COMPONENT CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-06 US disclosed
US-4137228-A HIGH TINCTORIAL STRENGTH, COLORFASTNESS CASSELLA AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-4033945-A Water-soluble trisazo 8-amino-naphthol-1 dyes CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1977-07-05 US disclosed
US-4024125-A Dis-azo pigments deriving from bis-diazotized diamino-2-phenyl-benzazolones HOECHST AKTIENGESELLSCHAFT (DT) 1977-05-17 US disclosed
US-4018735-A Anisotropic dopes of aromatic polyamides TEIJIN LIMITED (JA) 1977-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050176700-A1 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases REN, AGTR1, ACE MAPT 4578/4885KDM4E 799/4885GAA 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.