SCHEMBL2245118

SCHEMBL2245118

Nc1ccc2sc(-c3ccccc3)nc2c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.81
KDM4E B2RXH2 10/20 0.81
NPC1 O15118 9/20 0.81
RAB9A P51151 9/20 0.81
GAA P10253 7/20 0.81
NFKB1 P19838 6/20 0.81
NFKB2 Q00653 6/20 0.81
RELA Q04206 6/20 0.81
ALDH1A1 P00352 5/20 0.81
KMT2A Q03164 5/20 0.81
MEN1 O00255 4/20 0.81
POLB P06746 4/20 0.81
GFER P55789 2/20 0.81
SMN1; SMN2 Q16637 7/20 0.76
HPGD P15428 5/20 0.76
GLA P06280 4/20 0.76
PKM P14618 3/20 0.76
APP P05067 7/20 0.65
MMP9 P14780 1/20 0.65
MMP8 P22894 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29918176 0.89 MAPT (1.00) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL6399498 0.89 MAPT (1.00) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL6401979 0.88 MAPT (0.77) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL3194266 0.86 MAPT (1.00) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL19148568 0.83 MAPT (0.81) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL2242138 0.83 MAPT (0.82) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL2244906 0.83 MAPT (0.81) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL13650109 0.83 MAPT (0.69) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL19149498 0.83 KDM4E (0.65) MAPTKDM4ENPC1RAB9AGAA
SCHEMBL11778341 0.83 NPC1 (0.66) MAPTKDM4ENPC1RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110195932-A1 Drug Combinations for the Treatment of Duchenne Muscular Dystrophy SUMMIT (OXFORD) LIMITED (GB) 2011-08-11 US claimed
US-12413729-B2 Chroma quantization parameter adjustment in video encoding and decoding INTERDIGITAL VC HOLDINGS, INC. (US) 2025-09-09 US disclosed
CN-120129535-A Tissue factor antibody-drug conjugates and uses thereof 埃克塞里艾克西斯公司 2025-06-10 CN disclosed
CN-119152271-A Decoupling consistency regularization-based countermeasure training method and image classification method 中国人民解放军国防科技大学 2024-12-17 CN disclosed
EP-4422679-A1 IMMUNOGENIC FUSION PROTEINS AGAINST CORONAVIRUS Navicure Biopharmaceuticals Limited (WS) 2024-09-04 EP disclosed
WO-2024081996-A1 METHOD OF TREATING SEVERE ASTHMA CSL Innovation Pty Ltd (AU) 2024-04-25 WO disclosed
US-20240089437-A1 CHROMA QUANTIZATION PARAMETER ADJUSTMENT IN VIDEO ENCODING AND DECODING INTERDIGITAL VC HOLDINGS, INC. (US) 2024-03-14 US disclosed
CN-113195530-B Antibody fusion protein, preparation method and application thereof 长春金赛药业有限责任公司 2023-06-16 CN disclosed
CN-112961250-B Antibody fusion proteins and uses thereof 长春金赛药业有限责任公司 2023-06-06 CN disclosed
WO-2023076820-A1 IMMUNOGENIC FUSION PROTEINS AGAINST CORONAVIRUS NAVICURE BIOPHARMACEUTICALS LIMITED (WS) 2023-05-04 WO disclosed
EP-2170396-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BioMarin IGA Limited (BS) 2010-04-07 EP disclosed
US-7674809-B2 Anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production ROTTAPHARM S.P.A. (IT) 2010-03-09 US disclosed
US-20090075938-A1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT (OXFORD) LIMITED (GB) 2009-03-19 US disclosed
WO-2009019504-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2009-02-12 WO disclosed
EP-1986633-A2 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Summit Corporation Plc (GB) 2008-11-05 EP disclosed
WO-2007091106-A2 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2007-08-16 WO disclosed
US-20050197331-A1 Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production ROTTAPHARM SPA 2005-09-08 US disclosed
EP-1571142-A1 Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production Rottapharm S.p.A. (IT) 2005-09-07 EP disclosed
CN-1026322-C Process for preparing benzodumb azole derivatives TANABE SEIYAKU CO (JP) 1994-10-26 CN disclosed
CN-88101542-A Benzoxazole derivatives and process for preparing them 1988-10-05 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195932-A1 Drug Combinations for the Treatment of Duchenne Muscular Dystrophy PYGM, CPT1B, GYS1 MAPT 3113/4885KDM4E 3311/4885NPC1 2477/4885
US-20050197331-A1 Novel anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production NOS3, NOS1, NOS2 MAPT 4542/4885KDM4E 3052/4885NPC1 4082/4885
US-20090075938-A1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY NR0B1, NR0B2, NR3C1 MAPT 4858/4885KDM4E 2080/4885NPC1 3637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.