Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 16/20 | 0.52 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6401289 | 0.88 | NHERF1 (0.53) | PYGLNHERF1HRH4HRH3BCAT1 | |
| SCHEMBL6401020 | 0.88 | NHERF1 (0.58) | PYGLNHERF1BCAT1 | |
| SCHEMBL6400331 | 0.86 | NHERF1 (0.55) | PYGLNHERF1HRH4HRH3BCAT1 | |
| SCHEMBL6400295 | 0.84 | NHERF1 (0.55) | PYGLNHERF1BCAT1 | |
| SCHEMBL6402210 | 0.83 | NHERF1 (0.60) | PYGLNHERF1BCAT1 | |
| SCHEMBL6405183 | 0.82 | MEN1 (0.53) | PYGLNHERF1HRH4HRH3BCAT1 | |
| SCHEMBL4937039 | 0.79 | BCAT1 (0.57) | PYGLNHERF1BCAT1 | |
| SCHEMBL6400057 | 0.79 | NHERF1 (0.60) | PYGLNHERF1HRH4HRH3BCAT1 | |
| SCHEMBL6406416 | 0.78 | BCAT1 (0.67) | PYGLNHERF1HRH4HRH3BCAT1 | |
| SCHEMBL6401177 | 0.77 | KDM4E (0.68) | PYGLNHERF1BCAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | claimed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | claimed |
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | disclosed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | IDO1, GPR119, SLC5A1 | PYGL 96/4885NHERF1 332/4885HRH4 1853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.