Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206345 | 0.91 | DUSP3 (0.39) | DUSP3MAP2K1MAP2K2MAPTALDH1A1 | |
| SCHEMBL6400835 | 0.85 | DUSP3 (0.37) | DUSP3MAP2K1MAP2K2MAPTALDH1A1 | |
| SCHEMBL6207706 | 0.80 | ALDH1A1 (0.38) | DUSP3MAP2K1MAP2K2ALDH1A1KDM4E | |
| SCHEMBL6406299 | 0.80 | PIM1 (0.44) | MAP2K1MAP2K2MAPTALDH1A1KDM4E | |
| SCHEMBL6399775 | 0.79 | MAP2K1 (0.46) | MAP2K1MAP2K2ALDH1A1KDM4ETP53 | |
| SCHEMBL6208038 | 0.79 | PIM1 (0.45) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6406565 | 0.79 | PIM1 (0.39) | MAP2K1MAP2K2MAPTALDH1A1LMNA | |
| SCHEMBL6399813 | 0.78 | MAP2K1 (0.43) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6406148 | 0.78 | MAP2K1 (0.41) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6187892 | 0.78 | MAP2K1 (0.45) | MAP2K1MAP2K2PIM1CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | claimed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | DUSP3 80/4885MAP2K1 46/4885MAP2K2 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.