Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6400875 | 0.91 | DUSP3 (0.45) | DUSP3SMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL6187211 | 0.88 | MAP2K1 (0.44) | TDP1MAP2K1MAP2K2ALOX12PIM1 | |
| SCHEMBL6400835 | 0.82 | DUSP3 (0.37) | DUSP3LMNAMAPTALDH1A1HPGD | |
| SCHEMBL6207706 | 0.78 | ALDH1A1 (0.38) | DUSP3SMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL6399775 | 0.78 | MAP2K1 (0.46) | ALDH1A1HSD17B10KDM4ETP53MAP2K1 | |
| SCHEMBL6406299 | 0.78 | PIM1 (0.44) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL6206538 | 0.77 | ALOX12 (0.41) | SMN1; SMN2TDP1MAP2K1MAP2K2NPC1 | |
| SCHEMBL6208038 | 0.77 | PIM1 (0.45) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6406565 | 0.77 | PIM1 (0.39) | SMN1; SMN2LMNAGAATSHRMAPT | |
| SCHEMBL6399813 | 0.76 | MAP2K1 (0.43) | MAP2K1MAP2K2PIM1CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |