Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107438 | 0.80 | NPC1 (0.54) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL1685398 | 0.78 | KMT2A (0.56) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11066753 | 0.77 | NPC1 (0.54) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9834330 | 0.74 | KMT2A (0.61) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11064251 | 0.73 | KMT2A (0.50) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL10383197 | 0.73 | NPC1 (0.50) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11070922 | 0.73 | KMT2A (0.50) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11067037 | 0.72 | GSK3A (0.51) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11072116 | 0.70 | KMT2A (0.49) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11074111 | 0.70 | KMT2A (0.48) | NPC1RAB9AKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | claimed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | claimed |
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | disclosed |
| EP-1078266-B1 | HUMAN CHROMOGRANIN A (GgA) IMMUNOLOGIC ASSAY, ANTIBODIES, REAGENTS AND KITS FOR SAID ASSAY | CIS BIO INT (FR) | 2004-11-17 | — | — | EP | disclosed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-6632624-B1 | Use immunoassay for precise measurement of levels of intact chromogranin A and the levels of major fragments found in circulating blood | CIS BIO INTERNATIONAL (FR) | 2003-10-14 | — | — | US | disclosed |
| EP-1078266-A1 | HUMAN CHROMOGRANIN A (GgA) IMMUNOLOGIC ASSAY, ANTIBODIES, REAGENTS AND KITS FOR SAID ASSAY | CIS BIO INTERNATIONAL (FR) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058980-A1 | HUMAN CHROMOGRANIN A (GgA) IMMUNOLOGIC ASSAY, ANTIBODIES, REAGENTS AND KITS FOR SAID ASSAY | CIS BIO INTERNATIONAL (FR) | 1999-11-18 | — | — | WO | disclosed |
| US-5981264-A | PURE MICROORGANISM CULTURES PRODUCING FUNGICIDES; FOR TREATMENT OF PLANT DISEASE OR EFFECTIVE AS USE AS HERBICIDES | THE RESEARCH AND DEVELOPMENT INSTITUTE, INC. AT MONTANA STATE UNIVERSITY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5837685-A | PSEUDOMYCIN | RESEARCH AND DEVELOPMENT INSTITUTE INC. AT MONTANA STATE UNIVERSITY (US) | 1998-11-17 | — | — | US | disclosed |
| US-5576298-A | PSEUDOMYCIN | RESEARCH AND DEVELOPMENT INSTITUTE, INC. AT MONTANA STATE UNIVERSITY (US) | 1996-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | IDO1, GPR119, SLC5A1 | NPC1 706/4885RAB9A 1891/4885KMT2A 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.