Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 14/20 | 0.47 |
| ▸ | CCR3 | P51677 | 14/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6397887 | 0.77 | HRH1 (0.46) | HRH1CCR3KDM4EKCNH2FPR2 | |
| Ammonia Solution, Strong SCHEMBL6398869 | 0.76 | HRH1 (0.45) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL5369447 | 0.76 | HRH1 (0.56) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL5102799 | 0.74 | HRH1 (0.59) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL6402580 | 0.73 | HRH1 (0.48) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL27550980 | 0.73 | HRH1 (0.46) | HRH1CCR3KDM4EROCK1KCNH2 | |
| SCHEMBL5367457 | 0.71 | HRH1 (0.52) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL7600260 | 0.71 | HRH1 (0.48) | HRH1CCR3KDM4EKCNH2FPR2 | |
| SCHEMBL5194926 | 0.70 | HRH1 (0.62) | HRH1CCR3KCNH2 | |
| SCHEMBL14715736 | 0.70 | HRH1 (0.50) | HRH1CCR3KDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946478-B2 | Compounds | ASTRAZENECA AB (SE) | 2005-09-20 | — | — | US | claimed |
| US-6946478-B2 | Compounds | ASTRAZENECA AB (SE) | 2005-09-20 | — | — | US | disclosed |
| US-20030134840-A1 | Novel compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134840-A1 | Novel compounds | RPS4X, RPS4Y1, CYP4B1 | HRH1 802/4885CCR3 894/4885KDM4E 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.