Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 10/20 | 0.70 |
| ▸ | P2RX2 | Q9UBL9 | 10/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL638758 | 0.88 | P2RX3 (0.71) | P2RX3P2RX2NR1I2CYP2C9 | |
| SCHEMBL638719 | 0.83 | P2RX3 (1.00) | P2RX3P2RX2 | |
| SCHEMBL638720 | 0.83 | P2RX3 (0.74) | P2RX3P2RX2NR1I2 | |
| SCHEMBL1495784 | 0.81 | TDP1 (0.49) | P2RX3P2RX2NR1I2CYP2C9TDP1 | |
| SCHEMBL407644 | 0.80 | P2RX3 (0.47) | P2RX3P2RX2NR1I2CYP2C9GRIA2 | |
| SCHEMBL639691 | 0.80 | P2RX3 (1.00) | P2RX3P2RX2 | |
| SCHEMBL7947936 | 0.78 | CNR2 (0.48) | P2RX3P2RX2NR1I2CYP2C9TDP1 | |
| SCHEMBL3057697 | 0.77 | P2RX3 (0.45) | P2RX3P2RX2NR1I2CYP2C9TDP1 | |
| SCHEMBL1495521 | 0.76 | CA12 (0.51) | P2RX3P2RX2NR1I2CYP2C9TDP1 | |
| SCHEMBL3066007 | 0.76 | KDM4E (0.48) | P2RX3P2RX2NR1I2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081320-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-23 | — | — | US | disclosed |
| US-20170081320-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-23 | — | — | US | disclosed |
| US-20170081320-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-23 | — | — | US | disclosed |
| US-9173861-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173861-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173861-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2015-11-03 | — | — | US | disclosed |
| EP-2379518-B1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | disclosed |
| EP-2379518-B1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | disclosed |
| US-20120122886-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI (CN) | 2012-05-17 | — | — | US | disclosed |
| US-20120122886-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI (CN) | 2012-05-17 | — | — | US | disclosed |
| US-20120122886-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI (CN) | 2012-05-17 | — | — | US | disclosed |
| US-8119644-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | Roche Palo Alto LLP (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119644-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | Roche Palo Alto LLP (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2379518-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010069794-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| US-20100152203-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI | 2010-06-17 | — | — | US | disclosed |
| US-20100152203-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122886-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX2, P2RX7 | P2RX3 1/4885P2RX2 2/4885NR1I2 163/4885 |
| US-20170081320-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX2, P2RX7 | P2RX3 1/4885P2RX2 2/4885NR1I2 163/4885 |
| US-20100152203-A1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX2, P2RX7 | P2RX3 1/4885P2RX2 2/4885NR1I2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.