Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 13/20 | 0.74 |
| ▸ | P2RX2 | Q9UBL9 | 13/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639691 | 0.85 | P2RX3 (1.00) | P2RX3P2RX2 | |
| SCHEMBL638719 | 0.84 | P2RX3 (1.00) | P2RX3P2RX2 | |
| SCHEMBL638758 | 0.83 | P2RX3 (0.71) | P2RX3P2RX2NR1I2 | |
| SCHEMBL640133 | 0.83 | P2RX3 (0.70) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171464 | 0.76 | P2RX3 (0.51) | P2RX3P2RX2NR1I2 | |
| SCHEMBL3660372 | 0.76 | P2RX3 (0.45) | P2RX3P2RX2 | |
| SCHEMBL14837447 | 0.75 | P2RX3 (0.45) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2170842 | 0.74 | P2RX3 (0.43) | P2RX3P2RX2NR1I2 | |
| SCHEMBL18652127 | 0.72 | P2RX3 (0.72) | P2RX3P2RX2 | |
| SCHEMBL15936386 | 0.72 | P2RX3 (0.44) | P2RX3P2RX2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119644-B2 | Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists | Roche Palo Alto LLP (US) | 2012-02-21 | — | — | US | claimed |