Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 16/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198511 | 0.87 | CASP1 (0.49) | CASP1 | |
| SCHEMBL18328212 | 0.78 | MAPT (0.41) | CASP1ALDH1A1TDP1 | |
| SCHEMBL18159719 | 0.78 | TDP1 (0.39) | CASP1ALDH1A1TDP1 | |
| SCHEMBL10882651 | 0.78 | CASP1 (0.43) | CASP1ALDH1A1TDP1 | |
| SCHEMBL8869145 | 0.78 | CASP1 (0.43) | CASP1ALDH1A1TDP1 | |
| SCHEMBL991835 | 0.78 | CASP1 (0.43) | CASP1ALDH1A1TDP1 | |
| SCHEMBL1282757 | 0.77 | TSHR (0.45) | CASP1ALDH1A1TDP1 | |
| SCHEMBL10457949 | 0.76 | MAPT (0.41) | CASP1ALDH1A1TDP1 | |
| SCHEMBL10457950 | 0.76 | MAPT (0.41) | CASP1ALDH1A1TDP1 | |
| SCHEMBL2006527 | 0.75 | TDP1 (0.42) | CASP1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | IL1A, IL1B, IFNAR1 | CASP1 5/4885ALDH1A1 458/4885TDP1 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.