Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRN | P28799 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068398 | 1.00 | LCK (0.48) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL8734216 | 0.77 | RIPK1 (0.40) | ALDH1A1GRNSORT1RIPK1MEN1 | |
| SCHEMBL11658477 | 0.76 | ALDH1A1 (0.44) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL2776377 | 0.76 | ALDH1A1 (0.61) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL5965619 | 0.76 | ALDH1A1 (0.61) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL6897321 | 0.75 | ALDH1A1 (0.48) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL28316460 | 0.75 | RIPK1 (0.39) | ALDH1A1GRNSORT1RIPK1MEN1 | |
| SCHEMBL28314617 | 0.75 | RIPK1 (0.39) | ALDH1A1GRNSORT1RIPK1MEN1 | |
| SCHEMBL1691839 | 0.75 | ALDH1A1 (0.48) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL11022237 | 0.75 | ALDH1A1 (0.48) | LCKPPARDZDHHC20ZDHHC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215749-A | Apixaban intermediate and preparation method thereof | 浙江九洲药业股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-112462047-B | Nicarbazin detection kit and application thereof | 北京元恩生物技术有限公司 | 2023-02-07 | — | — | CN | disclosed |
| CN-114349780-B | Flusilazole hapten, antigen, antibody, detection device and detection method thereof | 广东江门中医药职业学院 | 2022-06-24 | — | — | CN | disclosed |
| CN-114349780-A | Flusilazole hapten, antigen, antibody, detection device and detection method thereof | 广东江门中医药职业学院 | 2022-04-15 | — | — | CN | disclosed |
| US-8791148-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-07-29 | — | — | US | disclosed |
| US-20120172335-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2012-07-05 | — | — | US | disclosed |
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |
| WO-2010128401-A9 | POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS | PRONOVA BIOPHARMA NORGE AS (NO) | 2011-12-08 | — | — | WO | disclosed |
| US-20100152168-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | ABBOTT GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| EP-2061769-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | Abbott GmbH & Co. KG (DE) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008025736-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | ABBOTT GMBH & CO. KG (DE) | 2008-03-06 | — | — | WO | disclosed |
| US-5990341-A | Diastereoselective synthesis hydroxyethylene dipeptide isosteres | EMORY UNIVERSITY (US) | 1999-11-23 | — | — | US | disclosed |
| US-5587514-A | Diastereoselective synthesis of hydroxyethylene dipeptide isosteres | EMORY UNIVERSITY (US) | 1996-12-24 | — | — | US | disclosed |
| WO-1995014655-A1 | DIASTEREOSELECTIVE SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES | EMORY UNIVERSITY (US) | 1995-06-01 | — | — | WO | disclosed |
| US-4474779-A | ANTIBIOTICS, BACTERICIDES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1984-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152168-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | AVPR2, AVPR1B, AVPR1A | LCK 4371/4885PPARD 1638/4885ZDHHC20 2859/4885 |
| US-20120172335-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | AVPR2, AVPR1B, AVPR1A | LCK 4371/4885PPARD 1638/4885ZDHHC20 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.