Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 6/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | PYGM | P11217 | 4/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6400106 | 0.81 | HRH4 (0.55) | HRH4NHERF1IDO1GUSBMEN1 | |
| SCHEMBL6400290 | 0.80 | HRH4 (0.53) | HRH4NHERF1IDO1GUSBMEN1 | |
| SCHEMBL6400322 | 0.76 | HRH4 (0.53) | HRH4NHERF1IDO1GUSBMEN1 | |
| SCHEMBL6400096 | 0.75 | HRH4 (0.51) | HRH4NHERF1IDO1GUSBMEN1 | |
| SCHEMBL6399693 | 0.71 | HRH4 (0.57) | HRH4NHERF1GUSBMEN1KMT2A | |
| SCHEMBL6400051 | 0.70 | HRH4 (0.53) | HRH4NHERF1GUSBMEN1KMT2A | |
| SCHEMBL6399564 | 0.70 | HRH4 (0.52) | HRH4NHERF1GUSBMEN1KMT2A | |
| SCHEMBL31058769 | 0.69 | NHERF1 (0.78) | NHERF1GUSBMEN1KMT2ANPC1 | |
| SCHEMBL6407409 | 0.69 | HRH4 (0.54) | HRH4NHERF1GUSBMEN1KMT2A | |
| SCHEMBL17149647 | 0.67 | PYGL (0.65) | NHERF1GUSBMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | disclosed |
| EP-1452526-A1 | INDOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054696-A1 | Indole compounds and medicinal use thereof | IDO1, GPR119, SLC5A1 | HRH4 1853/4885CNR1 259/4885NHERF1 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.