Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14319712 | 0.88 | HSD11B1 (0.50) | HSD11B1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL3611806 | 0.85 | ESR1 (0.54) | HSD11B1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL20138852 | 0.84 | KMT2A (0.49) | HSD11B1NPSR1MEN1KMT2ANPC1 | |
| SCHEMBL3615238 | 0.84 | MAOB (0.55) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL5963645 | 0.83 | HSD11B1 (0.47) | HSD11B1POLBNPSR1MEN1KMT2A | |
| SCHEMBL5183124 | 0.83 | SRC (0.51) | HSD11B1POLBMEN1KMT2ANPC1 | |
| SCHEMBL6154598 | 0.82 | HSD11B1 (0.44) | HSD11B1POLBNPC1ALDH1A1PPID | |
| SCHEMBL9437333 | 0.79 | MEN1 (0.51) | POLBNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL6400748 | 0.78 | CYP2C19 (0.53) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3610735 | 0.77 | POLB (0.46) | HSD11B1POLBMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004735-A1 | Method for inhibiting the replication of herpes viruses | AICURIS GMBH & CO. KG (DE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004735-A1 | Method for inhibiting the replication of herpes viruses | AICURIS GMBH & CO. KG (DE) | 2007-01-04 | — | — | US | disclosed |
| US-20050059658-A1 | Pyridazinone | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
| EP-1404657-A1 | PYRIDAZINONE | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003002541-A1 | PYRIDAZINONE | BAYER HEALTHCARE AG (DE) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | TYMP, TPMT, PDXK | HSD11B1 3509/4885POLB 368/4885NPSR1 3627/4885 |
| US-20070004735-A1 | Method for inhibiting the replication of herpes viruses | RPL35, PCNA, MCM5 | HSD11B1 2876/4885POLB 45/4885NPSR1 3709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.