Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543613 | 0.92 | LMNA (0.43) | CYP3A4LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL1544093 | 0.79 | CYP3A4 (0.48) | CYP3A4LMNAALDH1A1MAPTRAB9A | |
| SCHEMBL1544079 | 0.78 | LMNA (0.55) | CYP3A4LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL1543757 | 0.77 | POLB (0.55) | CYP3A4LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL1543530 | 0.77 | LMNA (0.57) | CYP3A4LMNAALDH1A1MAPTHPGD | |
| SCHEMBL6402043 | 0.76 | LMNA (0.43) | CYP3A4LMNAALDH1A1MAPTRAB9A | |
| SCHEMBL1544264 | 0.76 | LMNA (0.43) | CYP3A4LMNAALDH1A1MAPTRAB9A | |
| SCHEMBL1544318 | 0.76 | LMNA (0.51) | CYP3A4LMNAALDH1A1MAPTHPGD | |
| SCHEMBL1543844 | 0.76 | ALDH1A1 (0.64) | LMNAALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL1544243 | 0.75 | GRM5 (0.55) | LMNAALDH1A1MAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529045-A2 | NEW COMPOUNDS | Astra Zeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004014881-A2 | '1,2,4'OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRA ZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |